Recent evidence suggests that Vitamin D might be involved in cognitive function and mood regulation apart from its well-known role in bone and mineral metabolism. Decline in Vitamin D levels can affect many brain functions and neuronal development which may result in various psychological impairments like depression, dementia, etc. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the Role of Vitamin D in Mental Wellness. Vitamin D supplementation possibly offers favorable results in ADHD The impact of Vitamin D supplementation on the brain mapping and behavioral performance of 35 ADHD children was evaluated in a study. After 2 months, Vitamin D supplementation was associated with a 27.7 ng/ml greater improvement in Vitamin D levels compared to placebo from baseline (P = 0.001). Improvement in cognitive processing and function (identified by brain waves improvement) was positively associated with an improvement in ADHD symptoms (assessed by Connors scores). Vitamin D supplementation substantially improved cognitive function and processing in both eye open and closed conditions Vs. placebo. Mirhosseini H et al. Nutr Neurosci. 2024 Jun;27(6):566-576 Maintaining adequate Vitamin D levels might improve mental health in CKD A cohort study analyzed the relationship between Vitamin D deficiency (≤20 ng/mL) and the risk of major depression in 17,955 chronic kidney disease (CKD) patients. At 1-year, patients with Vitamin D deficiency had a 92% greater risk of developing major depression compared to control (≥30 ng/mL) and this correlation persisted throughout the 3-year follow-up. This relationship between Vitamin D deficiency and depression risk was consistent across CKD stages. The relative risk of major depression (Vs. control) was higher among male patients with Vitamin D deficiency (↑2.2-fold) compared to female (↑76%). Chen IW et al. Front Nutr. 2025 Jan 27;12:1540633 Vitamin D deficiency potentially elevates the risk of dementia The association of Vitamin D levels with cognitive impairment and dementia was assessed in a systematic review and meta-analysis of prospective studies. Among 23 included studies, Vitamin D was non-linearly correlated with dementia and Alzheimer’s disease (AD) risk. Vitamin D deficiency demonstrated a 1.4-fold, 1.5-fold and 34% higher risk of dementia, AD and cognitive impairment compared to control. Additionally, ~ 77.5 to 100 nmol/L of Vitamin D was optimal for lowering dementia risk and the AD risk decreased with > 40 nmol/L of Vitamin D level. Zhang XX et al. J Alzheimers Dis. 2024;98(2):373-385 Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom. For more information, please visit our public awareness initiative All Rights Reserved Fermenta Biotech Ltd.