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Vitamin D is essential for bone health and maintaining calcium and phosphorus homeostasis. Beyond this, it acts as an important regulator of the immune system, influencing both innate and adaptive immunity. Research shows Vitamin D affects how the body responds to pathogens and plays a key role in the prevention and progression of acute, chronic and autoimmune diseases. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the role of Vitamin D in Supporting Immunity.
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Maintaining Vitamin D levels might be beneficial for urinary tract health
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The association between serum Vitamin D levels and urinary tract infections (UTIs) was evaluated in a case-control study which enrolled 120 children aged 2-18 years. A significantly lower level of Vitamin D was noticed among participants with UTI as compared to the healthy individuals (17.7 ng/mL vs. 37.91 ng/mL). Additionally, 86.2% and 54.8% individuals with Vitamin D deficiency (<20 ng/mL) had pyelonephritis and cystitis infections, respectively, indicating a significant association between infection type and Vitamin D status. For predicting UTI, the optimal cut-off value of serum Vitamin D levels was determined as 20.15 ng/mL.
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| Piyadah Kouhsar M et al. Caspian J Intern Med. 2025 Oct 15;16(4):651-658 |
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Vitamin D supplementation may improve outcomes in rheumatoid arthritis
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A systematic review and meta-analysis investigated the impact of Vitamin D supplementation on the outcomes of rheumatoid arthritis. Among 11 included studies, Vitamin D supplementation resulted in a significant increase in the serum Vitamin D levels with a weighted mean difference (WMD) of +12.69 compared to the control group. Vitamin D supplementation also significantly improved disease activity [assessed by disease activity score-28 (DAS-28)] vs. control group. Additionally, the C-reactive protein and erythrocyte sedimentation rate were reduced by a WMD of -0.24 and -4.08, respectively, with Vitamin D supplementation vs. control group.
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| Ranjbar M et al. Heliyon. 2025 Feb 4;11(3):e42463 |
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Vitamin D deficiency potentially increases active tuberculosis risk
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A prospective, case-control study assessed the association between Vitamin D deficiency (VDD; <20 ng/ml) and incident active tuberculosis (TB) among 310 adults [TB patients (cases): 62 & subjects without active TB (controls): 248]. Compared to the control group, 73% more patients with TB had VDD. The mean Vitamin D concentration was also significantly lower by -3.2 ng/ml in patients with TB vs. control group. More than half of the TB patients with VDD had multiple lobar involvement. There was an inverse association between absolute Vitamin D level and incident active TB risk. |
| Hsu MS et al. J Microbiol Immunol Infect. 2024 Jun;57(3):490-497 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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