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Beyond skeletal health, research over recent decades has unveiled Vitamin D’s broader physiological functions, including immune modulation, inflammation regulation and cellular differentiation, sparking interest in its potential as an anti-cancer agent. Epidemiological studies often showcase marked association between low Vitamin D levels and an increased risk of colorectal, breast, prostate, head and neck cancer, etc. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the role of Vitamin D in cancer.
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Vitamin D supplementation may improve pathological response during chemotherapy in breast cancer
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A randomized clinical trial evaluated the impact of Vitamin D supplementation on the pathological complete response (pCR) in women with breast cancer undergoing neoadjuvant chemotherapy. At baseline (~20 days after diagnosis), mean serum Vitamin D levels indicated hypovitaminosis D in women randomized to receive either Vitamin D supplementation or placebo. At 6 months, Vitamin D supplementation was associated with an 80% higher pCR rate Vs. placebo. After adjusting for confounders, women with Vitamin D levels ≥20 mg/mL were 3.6-fold more likely to achieve a pCR Vs. those with Vitamin D deficiency (<20 ng/mL).
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| Omodei MS et al. Nutr Cancer. 2025;77(6):648-657 |
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Adequate Vitamin D levels probably lowers head and neck cancer risk
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The association between Vitamin D levels and clinical outcomes in head and neck cancer (HNC) patients was assessed in a systematic review. Among 16 included studies, the findings indicated that Vitamin D deficiency is highly prevalent (up to 95%) in HNC patients, wherein severe deficiencies were observed in advanced-stage and intensively treated patients. Additionally, there was an inverse association between Vitamin D levels and HNC risk, with higher serum Vitamin D levels linked to a 30-32% risk reduction. Although some studies lacked statistical significance, higher Vitamin D levels also correlated with improved survival and reduced recurrence.
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| Mot CI et al. Nutrients. 2025 Mar 21;17(7):1100 |
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Vitamin D levels might be negatively correlated with colorectal cancer risk
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A cross-sectional study analyzed the association between serum Vitamin D concentrations and colorectal cancer (CRC) risk among 43,678 adult participants. In the fully adjusted model, patients with Vitamin D deficiency (<30 nmol/L and 30 to <50 nmol/L) were 2-fold more likely to develop CRC compared to those with insufficiency (50 to <75 nmol/L). Furthermore, a significant inverse association between serum Vitamin D and CRC risk was evident at concentrations ≤75 nmol/L (P < 0.001), emphasizing the benefit of maintaining levels >75 nmol/L. Additionally, each 1 nmol/L increase in serum Vitamin D concentration was associated with a 2.3% risk reduction of CRC. |
| Wang Y et al. PLoS One. 2025 Mar 25;20(3):e0320335 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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